Channel Proteomes

Protein

Q02294 – Cav2.2

Cav2 Nano-Environments

Protein Details

Full Name Voltage-dependent N-type calcium channel subunit alpha-1B
Sequence Length 2336 AA
Molecular Weight 262,256 Da
Topology transmembrane
Subcellular Location plasma membrane
Biochemical Function ICT
UniProt Q02294

Antibody-Dependent Co-Purification

Solubilization Buffer
Antibody Group CL-91
Anti-CavBeta1
Anti-CavBeta2
Anti-CavBeta3
Anti-CavBeta4

Abundance in Anti-Cav2 APs (relative to Cav2 alpha 1)

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Subtype Preference

Preference for association of Cav2.2 with specific Cav2 alpha 1 subunits.

Not applicable.

Sequence Coverage

Coverage is 41.2% absolute, 72.8% relative. Sequence length is 2336 AA. 884 of 1244 AA found within and 79 of 1092 AA found outside of common MS mass range.

1
51
101
151
201
251
301
351
401
451
501
551
601
651
701
751
801
851
901
951
1001
1051
1101
1151
1201
1251
1301
1351
1401
1451
1501
1551
1601
1651
1701
1751
1801
1851
1901
1951
2001
2051
2101
2151
2201
2251
2301
MVRFGDELGG RYGGTGGGER ARGGGAGGAG GPGQGGLPPG QRVLYKQSIA
QR
ARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
ILATIIANCI VLALEQHLPD GDK
TPMSERL DDTEPYFIGI FCFEAGIKII
ALGFVFHK
GS YLRNGWNVMD FVVVLTEILA TAGTDFDLRT LRAVRVLRPL
K
LVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
K
ACFPNSTDA EPVGDFPCGK EAPARLCDSD TECREYWPGP NFGITNFDNI
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
VLGVLSGEFA K
ERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
AEEDK
NAEEK SPLDAVLKRA ATKKSRNDLI HAEEGEDRFV DLCAAGSPFA
R
ASLKSGKTE SSSYFRRKEK MFRFLIRRMV KAQSFYWVVL CVVALNTLCV
AMVHYNQPQR
LTTALYFAEF VFLGLFLTEM SLKMYGLGPR SYFRSSFNCF
DFGVIVGSIF EVVWAAIKPG TSFGISVLR
A LRLLRIFKVT KYWNSLRNLV
VSLLNSMK
SI ISLLFLLFLF IVVFALLGMQ LFGGQFNFQD ETPTTNFDTF
PAAILTVFQI LTGEDWNAVM YHGIESQGGV SK
GMFSSFYF IVLTLFGNYT
LLNVFLAIAV DNLANAQELT K
DEEEMEEAA NQKLALQKAK EVAEVSPMSA
ANISIAAR
QQ NSAKARSVWE QRASQLRLQN LRASCEALYS EMDPEERLRY
ASTR
HVRPDM KTHMDRPLVV EPGRDGLRGP AGNKSKPEGT EATEGADPPR
R
HHRHRDRDK TSASTPAGGE QDRTDCPKAE STETGAREER ARPRRSHSKE
APGADTQVR
C ERSRRHHRRG SPEEATEREP RRHRAHRHAQ DSSKEGKEGT
APVLVPK
GER RARHRGPRTG PRETENSEEP TRRHRAKHKV PPTLEPPERE
VAEK
ESNVVE GDKETRNHQP KEPRCDLEAI AVTGVGSLHM LPSTCLQKVD
EQPEDADNQR
NVTRMGSQPS DPSTTVHVPV TLTGPPGEAT VVPSANTDLE
GQAEGK
KEAE ADDVLRRGPR PIVPYSSMFC LSPTNLLRRF CHYIVTMRYF
EMVILVVIAL SSIALAAEDP VR
TDSFRNNA LKYMDYIFTG VFTFEMVIKM
IDLGLLLHPG AYFR
DLWNIL DFIVVSGALV AFAFSSFMGG SKGKDINTIK
SLR
VLRVLRP LKTIKRLPKL KAVFDCVVNS LKNVLNILIV YMLFMFIFAV
IAVQLFK
GKF FYCTDESKEL ERDCRGQYLD YEKEEVEAQP RQWKKYDFHY
DNVLWALLTL FTVSTGEGWP MVLK
HSVDAT YEEQGPSPGF RMELSIFYVV
YFVVFPFFFV NIFVALIIIT FQEQGDK
VMS ECSLEKNERA CIDFAISAKP
LTR
YMPQNKQ SFQYKTWTFV VSPPFEYFIM AMIALNTVVL MMKFYDAPYE
YELMLK
CLNI VFTSMFSLEC ILKIIAFGVL NYFRDAWNVF DFVTVLGSIT
DILVTEIANN FINLSFLR
LF RAARLIKLCR QGYTIRILLW TFVQSFKALP
YVCLLIAMLF FIYAIIGMQV FGNIALDDGT SINR
HNNFRT FLQALMLLFR
SATGEAWHEI MLSCLGNR
AC DPHANASECG SDFAYFYFVS FIFLCSFLML
NLFVAVIMDN FEYLTR
DSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF
EMLK
HMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR
TALEIK
LAPA GTKQHQCDAE LRKEISSVWA NLPQKTLDLL VPPHKPDEMT
VGK
VYAALMI FDFYKQNKTT RDQTHQAPGG LSQMGPVSLF HPLKATLEQT
QPAVLR
GARV FLRQKSATSL SNGGAIQTQE SGIKESLSWG TQRTQDVLYE
AR
APLERGHS AEIPVGQPGA LAVDVQMQNM TLRGPDGEPQ PGLESQGRAA
SMPR
LAAETQ PAPNASPMKR SISTLAPRPH GTQLCNTVLD RPPPSQVSHH
HHHR
CHRRRD KKQRSLEKGP SLSVDTEGAP STAAGSGLPH GEGSTGCRRE
R
KQERGRSQE RRQPSSSSSE KQRFYSCDRF GSREPPQPKP SLSSHPISPT
AALEPGPHPQ GSGSVNGSPL MSTSGASTPG R
GGRRQLPQT PLTPRPSITY
K
TANSSPVHF AEGQSGLPAF SPGRLSRGLS EHNALLQKEP LSQPLASGSR
IGSDPYLGQR
LDSEASAHNL PEDTLTFEEA VATNSGRSSR TSYVSSLTSQ
SHPLR
RVPNG YHCTLGLSTG VRARHSYHHP DQDHWC
Hint: Move your mouse over the sequence to see peptide-specific information.
Legend Within MS mass range Out of MS mass range
Identified RED VIOLET
Not identified BLACK GREY