Channel Proteomes

Protein

P54282 – Cav2.1

Cav2 Nano-Environments

Protein Details

Full Name Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Sequence Length 2212 AA
Molecular Weight 251,527 Da
Topology transmembrane
Subcellular Location plasma membrane
Biochemical Function ICT
UniProt P54282

Antibody-Dependent Co-Purification

Solubilization Buffer
Antibody Group CL-91
Anti-CavBeta1
Anti-CavBeta2
Anti-CavBeta3
Anti-CavBeta4

Abundance in Anti-Cav2 APs (relative to Cav2 alpha 1)

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Subtype Preference

Preference for association of Cav2.1 with specific Cav2 alpha 1 subunits.

Not applicable.

Sequence Coverage

Coverage is 39.2% absolute, 74.6% relative. Sequence length is 2212 AA. 791 of 1087 AA found within and 77 of 1125 AA found outside of common MS mass range.

1
51
101
151
201
251
301
351
401
451
501
551
601
651
701
751
801
851
901
951
1001
1051
1101
1151
1201
1251
1301
1351
1401
1451
1501
1551
1601
1651
1701
1751
1801
1851
1901
1951
2001
2051
2101
2151
2201
MARFGDEMPG RYGAGGGGSG PAAGVVVGAA GGRGAGGSRQ GGQPGAQRMY
K
QSMAQRART MALYNPIPVR QNCLTVNRSL FLFSEDNVVR KYAKKITEWP
PFEYMILATI IANCIVLALE QHLPDDDK
TP MSERLDDTEP YFIGIFCFEA
GIK
IVALGFA FHKGSYLRNG WNVMDFVVVL TGILATVGTE FDLRTLRAVR
VLRPLK
LVSG IPSLQVVLKS IMKAMIPLLQ IGLLLFFAIL IFAIIGLEFY
MGK
FHTTCFE EGTDDIQGES PAPCGTEEPA RTCPNGTKCQ PYWEGPNNGI
TQFDNILFAV LTVFQCITME GWTDLLYNSN DASGNTWNWL YFIPLIIIGS
FFMLNLVLGV LSGEFAK
ERE RVENRRAFLK LRRQQQIERE LNGYMEWISK
AEEVILAEDE TDVEQR
HPFD GALRRATLKK SKTDLLNPEE AEDQLADIAS
VGSPFAR
ASI KSAKLENSTF FHKKERRMRF YIRRMVKTQA FYWTVLSLVA
LNTLWLAIVH YNQPEWLSDF LYYAEFIFLG LFMSEMFIK
M YGLGTRPYFH
SSFNCFDCGV IIGSIFEVIW AVIKPGTSFG ISVLR
ALRLL RIFKVTKYWA
SLR
NLVVSLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFDEGTPP
TNFDTFPAAI MTVFQILTGE DWNEVMYDEI K
SQGGVQGGM VFSIYFIVLT
LFGNYTLLNV FLAIAVDNLA NAQELTK
DEQ EEEEAANQKL ALQKAKEVAE
VSPLSAANMS IAVK
EQQKNQ KPAKSVWEQR TSEMRKQNLL ASREALYGDA
AER
WPTTYAR PLRPDVKTHL DRPLVVDPQE NRNNNTNKSR APEALRQTAR
PR
ESARDPDA RRAWPSSPER APGREGPYGR ESEPQQREHA PPREHVPWDA
DPER
AKAGDA PRRHTHRPVA EGEPRRHRAR RRPGDEPDDR PERRPRPRDA
TRPAR
AADGE GDDGERKRRH RHGPPAHDDR ERRHRRRKES QGSGVPMSGP
NLSTTRPIQQ DLGR
QDLPLA EDLDNMKNNK LATGEPASPH DSLGHSGLPP
SPAK
IGNSTN PGPALATNPQ NAASRRTPNN PGNPSNPGPP KTPENSLIVT
NPSSTQPNSA K
TARKPEHMA VEIPPACPPL NHTVVQVNKN ANPDPLPKKE
EEK
KEEEEAD PGEDGPKPMP PYSSMFILST TNPLRRLCHY ILNLRYFEMC
ILMVIAMSSI ALAAEDPVQP NAPR
NNVLRY FDYVFTGVFT FEMVIKMIDL
GLVLHQGAYF R
DLWNILDFI VVSGALVAFA FTGNSKGKDI NTIKSLRVLR
VLRPLK
TIKR LPKLKAVFDC VVNSLKNVFN ILIVYMLFMF IFAVVAVQLF
K
GKFFHCTDE SKEFERDCRG KYLLYEKNEV KARDREWKKY DFHYDNVLWA
LLTLFTVSTG EGWPQVLK
HS VDATFENQGP SPGYRMEMSI FYVVYFVVFP
FFFVNIFVAL IIITFQEQGD K
MMEEYSLEK NERACIDFAI SAKPLTRHMP
QNK
QSFQYRM WQFVVSPPFE YTIMAMIALN TIVLMMKFYG ASVAYENALR
VFNIVFTSLF SLECVLK
VMA FGILNYFRDA WNIFDFVTVL GSITDILVTE
FGNNFINLSF LR
LFRAARLI KLLRQGYTIR ILLWTFVQSF KALPYVCLLI
AMLFFIYAII GMQVFGNIGI DGEDEDSDED EFQITEHNNF R
TFFQALMLL
FR
SATGEAWH NIMLSCLSGK PCDKNSGIQK PECGNEFAYF YFVSFIFLCS
FLMLNLFVAV IMDNFEYLTR
DSSILGPHHL DEYVRVWAEY DPAACGRIHY
K
DMYSLLRVI SPPLGLGKKC PHRVACKRLL RMDLPVADDN TVHFNSTLMA
LIR
TALDIKI AKGGADKQQM DAELRKEMMA IWPNLSQKTL DLLVTPHKST
DLTVGK
IYAA MMIMEYYRQS KAKKLQAMRE EQNRTPLMFQ RMEPPSPTQE
GGPSQNALPS TQLDPGGGLM AQESSMK
ESP SWVTQRAQEM FQKTGTWSPE
R
GPPIDMPNS QPNSQSVEMR EMGTDGYSDS EHYLPMEGQT RAASMPRLPA
ENQR
RRGRPR GNNLSTISDT SPMKRSASVL GPKARRLDDY SLERVPPEEN
QR
YHQRRRDR GHRTSERSLG RYTDVDTGLG TDLSMTTQSG DLPSKDRDQD
R
GRPKDRKHR PHHHHHHHHH HPPAPDRERY AQERPDTGRA RAREQRWSRS
PSEGR
EHATH RQ
Hint: Move your mouse over the sequence to see peptide-specific information.
Legend Within MS mass range Out of MS mass range
Identified RED VIOLET
Not identified BLACK GREY